Author: plpointer

In a new study, researchers from the Wisconsin Institute for Discovery (WID) have created a software tool that can help reveal biological pathways of a notorious pathogenic fungus. Aspergillus fumigatus, which is found worldwide, can infiltrate a human body and quickly overwhelm the immune system. In immunocompromised individuals, this fungus can cause major damage and has a high mortality rate. The new tool may eventually help researchers address the problems caused by A. fumigatus. 

In collaboration with the Feyza Lab, Khagani Eynullazada, a grad student from Sushmita Roy’s lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.

Together with the Randy Ashton’s lab and his former lab member, Nisha Iyer, we developed a unique resource mapping the gene expression changes that mark differences between neuronal cell subtypes along the hindbrain and spinal cord. Junha Shin from the Roy lab developed and applied dimensionality reduction and clustering approaches to analyze single cell datasets …

When considering evolution, we often think first about the visible physiological changes that species undergo. But changes in phenotype — those physical manifestations — are only the most apparent end results of intricate processes that occur at many molecular levels, including in the DNA, gene expression, protein expression, and histone modification levels. Through genomic tools, …

Viswesh Periyasamy presented a poster in May at the Great Lakes Bioinformatics Consortium 2019 Conference (GLBIO) on the topic of gene regulatory network inference. This is a method to recover the interactions and relationships between genes. His research goal, in his own words, “is to better understand how gene mutations responsible for degenerative eye disease can affect the underlying mechanisms in which genes interact with each other.”